Biostatistics Blog 2
September 22nd, 2016
Blog Assignment: Example of a peer reviewed journal article with experimental or observation study method. A reflection piece on the observational study explained in the paper/experimental design that is used (between 300-500 words)
Due 1:00pm on September 23, 2016 (Please post it before our lab, so we can discuss the design examples in your sample articles)
In this study, the researchers were focusing on the prevalence of congenital heart disease (CHD) in newborn babies, particularly in Northern India. In first world countries, congenital heart disease is the main cause of death within the first year of life, however, in third world and developing countries, there is little data that relates to CHD and newborns.1 The objective of this study was to observe the number of babies born with a CHD in a hospital located in Northern India. Specifically, this was a cross sectional study that was conducted in a pediatric hospital over a three-year period, and only babies born during a specific eight-hour time frame were used.1 After birth, normal tests were conducted and an echocardiogram was administered to determine if the newborns were suffering from a CHD.1
In this study, a total of 20,307 newborns were screened for congenital heart diseases. Of these, “874 had abnormal echocardiograms, 687 had insignificant echocardiograms, 164 had significant congenital heart diseases, and 24 had abnormal cardiac findings.”1 Those born with a significant congenital heart disease had a birth prevalence rate of 8.07 per 1000 live births. In the study, 131 babies had acyanotic CHD, 93 had a minor CHD and 38 had a major acyanotic CHD. These yield birth prevalence rates of 4.58 per 1000 live births and 1.87 per 1000 live births.1 Prior to this particular study, there had been inconsistent data relating to CHD in newborns. The range found in literature was 1.3-13.28 per 1000 live births.1 This study allowed researchers to give a relatively accurate number that described the prevalence of CHD in babies born in Northern India. In this study, the birth prevalence of CHD in newborns delivered in Northern India was 8.07 per 1000 live births.1 Before the data was deduced, the researchers initially predicted that the prevalence would be similar to the rest of the world. Interestingly enough, the prevalence of CHD in newborns delivered in India was very close to the prevalence in the rest of the world.1 This research has many important implications because it highlights some of the problems faced by newborns in developing countries. Many of these countries lack significant medical/research funding, and the results may help certain hospitals/medical centers secure the critical funding they need to help future newborns that may suffer from a CHD.
(1) Saxena, A.; Mehta, A.; Sharma, M.; Salhan, S.; Kalaivani, M.; Ramakrishnan, S. 2016, 9 (3), 205–209.